E21D (p.Glu21Asp) variant of XIAP (E3 ubiquitin-protein ligase XIAP)
E21D (p.Glu21Asp) in XIAP (E3 ubiquitin-protein ligase XIAP) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
E21D (p.Glu21Asp) variant details
- p.Glu21Asp
- cosmic curated COSV10817
- Missense
- Variant Prioritization Score for Impact Estimate 0.199
- REVEL 0.08
- CADD 19.20
- PolyPhen-2 0.21
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available