S62W (p.Ser62Trp) variant of WWTR1 (Q9GZV5)
S62W (p.Ser62Trp) in WWTR1 (Q9GZV5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
S62W (p.Ser62Trp) variant details
- p.Ser62Trp
- NCI-TCGA Cosmic COSV6229
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.687
- REVEL 0.59
- CADD 32.00
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available