P11L (p.Pro11Leu) variant of WWTR1 (Q9GZV5)
P11L (p.Pro11Leu) in WWTR1 (Q9GZV5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P11L (p.Pro11Leu) variant details
- p.Pro11Leu
- cosmic curated COSV10064
- gnomAD rs1435169768
- Missense
- Variant Prioritization Score for Impact Estimate 0.391
- REVEL 0.17
- CADD 24.40
- PolyPhen-2 0.01
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available
- WWTR1 WW domain domainome 1.0: score -0.493