M36L (p.Met36Leu) variant of WWTR1 (Q9GZV5)
M36L (p.Met36Leu) in WWTR1 (Q9GZV5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, experimental measurements, and structural context.
M36L (p.Met36Leu) variant details
- p.Met36Leu
- ExAC rs766298507
- gnomAD rs766298507
- Missense
- Variant Prioritization Score for Impact Estimate 0.259
- REVEL 0.14
- CADD 22.10
- PolyPhen-2 0.00
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available
- WWTR1 WW domain domainome 1.0: score -0.992