Q446L (p.Gln446Leu) variant of WT1 (Wilms tumor protein)
Q446L (p.Gln446Leu) in WT1 (Wilms tumor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, published literature, and structural context.
Q446L (p.Gln446Leu) variant details
- p.Gln446Leu
- rs533043871
- gnomAD 11-32392034-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.436
- REVEL 0.34
- MetaLR 0.08
- MetaSVM -1.12
- CADD 29.30
- PolyPhen-2 0.93
- SIFT 0.05
- Population evidence available
- Structural context available
- Literature evidence available