F425I (p.Phe425Ile) variant of WT1 (Wilms tumor protein)
F425I (p.Phe425Ile) in WT1 (Wilms tumor protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data, published literature, and structural context.
F425I (p.Phe425Ile) variant details
- p.Phe425Ile
- rs28941779
- gnomAD 11-32392026-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.652
- REVEL 0.68
- MetaLR 0.53
- MetaSVM 0.20
- CADD 29.50
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available
- Cited in: Exon 9 mutations in the WT1 gene, without influencing KTS splice isoforms, are also responsible for Frasier syndrome. (PMID 10571943)