S63F (p.Ser63Phe) variant of WRN (Q14191)
S63F (p.Ser63Phe) in WRN (Q14191) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data, published literature, and structural context.
S63F (p.Ser63Phe) variant details
- p.Ser63Phe
- gnomAD 8-31059244-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.552
- REVEL 0.39
- CADD 25.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- Literature evidence available