R25T (p.Arg25Thr) variant of WRN (Q14191)
R25T (p.Arg25Thr) in WRN (Q14191) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data, published literature, and structural context.
R25T (p.Arg25Thr) variant details
- p.Arg25Thr
- gnomAD 8-31058521-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.0696
- REVEL 0.04
- CADD 6.73
- PolyPhen-2 0.00
- SIFT 0.49
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available