C15Y (p.Cys15Tyr) variant of WRN (Q14191)
C15Y (p.Cys15Tyr) in WRN (Q14191) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
C15Y (p.Cys15Tyr) variant details
- p.Cys15Tyr
- gnomAD rs1395511634
- Missense
- Variant Prioritization Score for Impact Estimate 0.193
- REVEL 0.06
- CADD 13.50
- PolyPhen-2 0.00
- SIFT 0.32
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available