G74A (p.Gly74Ala) variant of VWF (von Willebrand factor)
G74A (p.Gly74Ala) in VWF (von Willebrand factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
G74A (p.Gly74Ala) variant details
- p.Gly74Ala
- ExAC rs777859406
- TOPMed rs777859406
- gnomAD rs777859406
- Missense
- Variant Prioritization Score for Impact Estimate 0.364
- REVEL 0.18
- MetaLR 0.18
- MetaSVM -0.92
- CADD 23.50
- PolyPhen-2 1.00
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available