T222I (p.Thr222Ile) variant of VPS35 (Q96QK1)
T222I (p.Thr222Ile) in VPS35 (Q96QK1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
T222I (p.Thr222Ile) variant details
- p.Thr222Ile
- gnomAD rs1163092596
- Missense
- Variant Prioritization Score for Impact Estimate 0.642
- REVEL 0.53
- CADD 28.30
- PolyPhen-2 0.92
- SIFT 0.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available