K14N (p.Lys14Asn) variant of VPS35 (Q96QK1)
K14N (p.Lys14Asn) in VPS35 (Q96QK1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
K14N (p.Lys14Asn) variant details
- p.Lys14Asn
- NCI-TCGA Cosmic COSV5448
- cosmic curated COSV54480
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- REVEL 0.26
- CADD 23.80
- PolyPhen-2 0.77
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available