K64T (p.Lys64Thr) variant of VPS13C (Q709C8)

Name: VPS13C K64T (p.Lys64Thr) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-10-26
License: https://catvariant.com/terms-of-use

K64T (p.Lys64Thr) in VPS13C (Q709C8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.

K64T (p.Lys64Thr) variant details

p.Lys64Thr
NCI-TCGA TCGA novel
TOPMed rs903266148
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.655
REVEL 0.65
ESM-1b 0.91
AlphaMissense 0.23
MetaLR 0.64
MetaSVM 0.36
CADD 26.10
UniProt: Variant assessed as somatic; moderate impact.
Most common in the Non-Finnish European population (allele frequency 9.1e-07)
Structural context available