Y25C (p.Tyr25Cys) variant of VKORC1 (Q9BQB6)
Y25C (p.Tyr25Cys) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
Y25C (p.Tyr25Cys) variant details
- p.Tyr25Cys
- gnomAD rs1484691721
- Missense
- Variant Prioritization Score for Impact Estimate 0.761
- REVEL 0.90
- CADD 29.20
- PolyPhen-2 1.00
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available