W10L (p.Trp10Leu) variant of VKORC1 (Q9BQB6)
W10L (p.Trp10Leu) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
W10L (p.Trp10Leu) variant details
- p.Trp10Leu
- ExAC rs766721996
- gnomAD rs766721996
- Missense
- Variant Prioritization Score for Impact Estimate 0.375
- REVEL 0.39
- CADD 22.50
- PolyPhen-2 0.00
- SIFT 0.03
- Most common in the 1KG:GIH population (allele frequency 0.0053)
- Structural context available