W10C (p.Trp10Cys) variant of VKORC1 (Q9BQB6)
W10C (p.Trp10Cys) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
W10C (p.Trp10Cys) variant details
- p.Trp10Cys
- ExAC rs763425395
- TOPMed rs763425395
- gnomAD rs763425395
- Missense
- Variant Prioritization Score for Impact Estimate 0.533
- REVEL 0.61
- CADD 24.10
- PolyPhen-2 0.65
- SIFT 0.01
- Most common in the 1KG:IBS population (allele frequency 0.017)
- Structural context available