V66L (p.Val66Leu) variant of VKORC1 (Q9BQB6)
V66L (p.Val66Leu) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data, published literature, and structural context.
V66L (p.Val66Leu) variant details
- p.Val66Leu
- gnomAD 16-31093399-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.54
- REVEL 0.57
- CADD 23.10
- PolyPhen-2 0.99
- SIFT 0.45
- Most common in the Ashkenazi Jewish population (allele frequency 7.7e-05)
- Structural context available
- Literature evidence available