V45M (p.Val45Met) variant of VKORC1 (Q9BQB6)
V45M (p.Val45Met) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
V45M (p.Val45Met) variant details
- p.Val45Met
- TOPMed rs1198062672
- Missense
- Variant Prioritization Score for Impact Estimate 0.625
- REVEL 0.67
- CADD 26.70
- PolyPhen-2 0.96
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.0011)
- Structural context available