S74G (p.Ser74Gly) variant of VKORC1 (Q9BQB6)
S74G (p.Ser74Gly) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data, published literature, and structural context.
S74G (p.Ser74Gly) variant details
- p.Ser74Gly
- gnomAD 16-31093375-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.671
- REVEL 0.71
- CADD 24.10
- PolyPhen-2 0.81
- SIFT 0.06
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available