R61S (p.Arg61Ser) variant of VKORC1 (Q9BQB6)
R61S (p.Arg61Ser) in VKORC1 (Q9BQB6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
R61S (p.Arg61Ser) variant details
- p.Arg61Ser
- NCI-TCGA TCGA novel
- TOPMed rs1303260087
- gnomAD rs1303260087
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.379
- REVEL 0.52
- CADD 14.60
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available