R37W (p.Arg37Trp) variant of VKORC1 (Q9BQB6)
R37W (p.Arg37Trp) in VKORC1 (Q9BQB6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
R37W (p.Arg37Trp) variant details
- p.Arg37Trp
- rs1389217886
- gnomAD rs1389217886
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.314
- REVEL 0.31
- CADD 22.80
- PolyPhen-2 0.45
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available