R12P (p.Arg12Pro) variant of VKORC1 (Q9BQB6)
R12P (p.Arg12Pro) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.80 / 1. The record also includes population frequency data and structural context.
R12P (p.Arg12Pro) variant details
- p.Arg12Pro
- gnomAD rs1291155948
- Missense
- Variant Prioritization Score for Impact Estimate 0.796
- REVEL 0.88
- CADD 25.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the 1KG:GIH population (allele frequency 0.0053)
- Structural context available