N77K (p.Asn77Lys) variant of VKORC1 (Q9BQB6)
N77K (p.Asn77Lys) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data, published literature, and structural context.
N77K (p.Asn77Lys) variant details
- p.Asn77Lys
- gnomAD 16-31093364-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.618
- REVEL 0.80
- CADD 24.90
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available