D73Y (p.Asp73Tyr) variant of VKORC1 (Q9BQB6)
D73Y (p.Asp73Tyr) in VKORC1 (Q9BQB6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data, published literature, and structural context.
D73Y (p.Asp73Tyr) variant details
- p.Asp73Tyr
- gnomAD 16-31093378-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.764
- REVEL 0.83
- CADD 25.40
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available