T33M (p.Thr33Met) variant of VIM (Vimentin)
T33M (p.Thr33Met) in VIM (Vimentin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
T33M (p.Thr33Met) variant details
- p.Thr33Met
- rs1344328729
- NCI-TCGA Cosmic COSV9981
- cosmic curated COSV99813
- gnomAD rs1344328729
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.24
- CADD 22.30
- PolyPhen-2 0.02
- SIFT 0.23
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 9e-05)
- Structural context available