R83W (p.Arg83Trp) variant of VCP (P55072)
R83W (p.Arg83Trp) in VCP (P55072) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.84 / 1. The record also includes population frequency data and structural context.
R83W (p.Arg83Trp) variant details
- p.Arg83Trp
- NCI-TCGA Cosmic COSV6272
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.839
- REVEL 0.92
- CADD 32.00
- PolyPhen-2 0.98
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available