K6N (p.Lys6Asn) variant of VCAN (Versican core protein)
K6N (p.Lys6Asn) in VCAN (Versican core protein) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
K6N (p.Lys6Asn) variant details
- p.Lys6Asn
- Ensembl rs868477733
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.128
- REVEL 0.08
- CADD 18.00
- PolyPhen-2 0.13
- SIFT 0.03
- ClinVar: Uncertain significance (not provided)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available