L17L (p.Leu17Leu) variant of UGT1A1 (UDP-glucuronosyltransferase 1A1)

Name: UGT1A1 L17L (p.Leu17Leu) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-09
License: https://catvariant.com/terms-of-use

L17L (p.Leu17Leu) in UGT1A1 (UDP-glucuronosyltransferase 1A1) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.

L17L (p.Leu17Leu) variant details

p.Leu17Leu
rs753493472
gnomAD 2-233760338-G-C
Synonymous
Variant Prioritization Score for Impact Estimate 0.198
CADD 4.97
Most common in the HGDP:MBUTI population (allele frequency 0.083)
Structural context available
Literature evidence available