S133P (p.Ser133Pro) variant of TYK2 (P29597)
S133P (p.Ser133Pro) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
S133P (p.Ser133Pro) variant details
- p.Ser133Pro
- ExAC rs751242030
- gnomAD rs751242030
- Missense
- Variant Prioritization Score for Impact Estimate 0.135
- REVEL 0.11
- CADD 10.10
- PolyPhen-2 0.01
- SIFT 0.11
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available