P2L (p.Pro2Leu) variant of TYK2 (P29597)
P2L (p.Pro2Leu) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
P2L (p.Pro2Leu) variant details
- p.Pro2Leu
- TOPMed rs1285567005
- gnomAD rs1285567005
- Missense
- Variant Prioritization Score for Impact Estimate 0.39
- REVEL 0.22
- CADD 22.20
- PolyPhen-2 0.18
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available