L99P (p.Leu99Pro) variant of TYK2 (P29597)
L99P (p.Leu99Pro) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
L99P (p.Leu99Pro) variant details
- p.Leu99Pro
- cosmic curated COSV10636
- ExAC rs775200017
- TOPMed rs775200017
- gnomAD rs775200017
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.53
- CADD 22.50
- PolyPhen-2 0.82
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available