L167R (p.Leu167Arg) variant of TYK2 (P29597)
L167R (p.Leu167Arg) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
L167R (p.Leu167Arg) variant details
- p.Leu167Arg
- gnomAD rs1421177533
- Missense
- Variant Prioritization Score for Impact Estimate 0.627
- REVEL 0.69
- CADD 25.90
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available