L152R (p.Leu152Arg) variant of TYK2 (P29597)
L152R (p.Leu152Arg) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data and structural context.
L152R (p.Leu152Arg) variant details
- p.Leu152Arg
- gnomAD rs1355892968
- Missense
- Variant Prioritization Score for Impact Estimate 0.682
- REVEL 0.69
- CADD 29.70
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available