L152F (p.Leu152Phe) variant of TYK2 (P29597)
L152F (p.Leu152Phe) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L152F (p.Leu152Phe) variant details
- p.Leu152Phe
- ExAC rs745894180
- TOPMed rs745894180
- gnomAD rs745894180
- Missense
- Variant Prioritization Score for Impact Estimate 0.448
- REVEL 0.34
- CADD 25.80
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available