H158R (p.His158Arg) variant of TYK2 (P29597)
H158R (p.His158Arg) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
H158R (p.His158Arg) variant details
- p.His158Arg
- ExAC rs770297599
- TOPMed rs770297599
- gnomAD rs770297599
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- REVEL 0.13
- CADD 21.30
- PolyPhen-2 0.42
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available