F46S (p.Phe46Ser) variant of TYK2 (P29597)
F46S (p.Phe46Ser) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
F46S (p.Phe46Ser) variant details
- p.Phe46Ser
- gnomAD rs1222690580
- Missense
- Variant Prioritization Score for Impact Estimate 0.55
- REVEL 0.51
- CADD 23.10
- PolyPhen-2 0.41
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available