C57S (p.Cys57Ser) variant of TYK2 (P29597)
C57S (p.Cys57Ser) in TYK2 (P29597) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
C57S (p.Cys57Ser) variant details
- p.Cys57Ser
- TOPMed rs2042242880
- gnomAD rs2042242880
- Missense
- Variant Prioritization Score for Impact Estimate 0.672
- REVEL 0.67
- CADD 24.60
- PolyPhen-2 0.98
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available