D33N (p.Asp33Asn) variant of TUBA1A (Tubulin alpha-1A chain)
D33N (p.Asp33Asn) in TUBA1A (Tubulin alpha-1A chain) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
D33N (p.Asp33Asn) variant details
- p.Asp33Asn
- NCI-TCGA Cosmic COSV9985
- cosmic curated COSV99853
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.392
- REVEL 0.30
- MetaLR 0.36
- MetaSVM -0.42
- CADD 23.30
- PolyPhen-2 0.25
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 5.6e-05)
- Structural context available