S25P (p.Ser25Pro) variant of TSHR (Thyrotropin receptor)
S25P (p.Ser25Pro) in TSHR (Thyrotropin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
S25P (p.Ser25Pro) variant details
- p.Ser25Pro
- TOPMed rs1886633581
- Missense
- Variant Prioritization Score for Impact Estimate 0.236
- REVEL 0.06
- CADD 3.60
- PolyPhen-2 0.00
- SIFT 0.66
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available