P45S (p.Pro45Ser) variant of TRPM4 (Q8TD43)
P45S (p.Pro45Ser) in TRPM4 (Q8TD43) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
P45S (p.Pro45Ser) variant details
- p.Pro45Ser
- ExAC rs765781527
- TOPMed rs765781527
- gnomAD rs765781527
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.09
- ESM-1b 0.00
- AlphaMissense 0.08
- CADD 0.93
- PolyPhen-2 0.00
- SIFT 0.69
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available