p.Ile15dup variant of TREX1 (Three-prime repair exonuclease 1)

Name: TREX1 p.Ile15dup variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-22
License: https://catvariant.com/terms-of-use

p.Ile15dup in TREX1 (Three-prime repair exonuclease 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, published literature, and structural context.

p.Ile15dup variant details

rs2040322179
gnomAD 3-48466695-C-CTCA
Inframe Insertion
Variant Prioritization Score for Impact Estimate 0.438
CADD 20.90
Most common in the 1KG:MXL population (allele frequency 0.0081)
Structural context available
Literature evidence available