F26L (p.Phe26Leu) variant of TREX1 (Three-prime repair exonuclease 1)
F26L (p.Phe26Leu) in TREX1 (Three-prime repair exonuclease 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
F26L (p.Phe26Leu) variant details
- p.Phe26Leu
- ExAC rs772753856
- gnomAD rs772753856
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- CADD 20.20
- PolyPhen-2 0.23
- SIFT 0.59
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available