S45T (p.Ser45Thr) variant of TRDN (Triadin)
S45T (p.Ser45Thr) in TRDN (Triadin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
S45T (p.Ser45Thr) variant details
- p.Ser45Thr
- NCI-TCGA Cosmic COSV1005
- cosmic curated COSV10052
- NCI-TCGA Cosmic COSV6212
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.491
- REVEL 0.28
- CADD 24.70
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available