G85C (p.Gly85Cys) variant of TRDN (Triadin)
G85C (p.Gly85Cys) in TRDN (Triadin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
G85C (p.Gly85Cys) variant details
- p.Gly85Cys
- cosmic curated COSV10522
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.53
- REVEL 0.34
- CADD 25.90
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.5e-05)
- Structural context available