V58A (p.Val58Ala) variant of TRAF6 (TNF receptor-associated factor 6)
V58A (p.Val58Ala) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
V58A (p.Val58Ala) variant details
- p.Val58Ala
- ExAC rs772870667
- gnomAD rs772870667
- Missense
- Variant Prioritization Score for Impact Estimate 0.481
- REVEL 0.42
- MetaLR 0.50
- MetaSVM -0.21
- CADD 22.90
- PolyPhen-2 0.05
- SIFT 0.26
- Most common in the East Asian population (allele frequency 7.6e-05)
- Structural context available