T42M (p.Thr42Met) variant of TRAF6 (TNF receptor-associated factor 6)
T42M (p.Thr42Met) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
T42M (p.Thr42Met) variant details
- p.Thr42Met
- TOPMed rs759328711
- gnomAD rs759328711
- Missense
- Variant Prioritization Score for Impact Estimate 0.359
- REVEL 0.17
- MetaLR 0.45
- MetaSVM -0.54
- CADD 20.50
- PolyPhen-2 0.01
- SIFT 0.24
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available