P62L (p.Pro62Leu) variant of TRAF6 (TNF receptor-associated factor 6)
P62L (p.Pro62Leu) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
P62L (p.Pro62Leu) variant details
- p.Pro62Leu
- TOPMed rs1859712360
- Missense
- Variant Prioritization Score for Impact Estimate 0.634
- REVEL 0.62
- MetaLR 0.49
- MetaSVM 0.04
- CADD 23.50
- PolyPhen-2 0.12
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available