P163L (p.Pro163Leu) variant of TRAF6 (TNF receptor-associated factor 6)
P163L (p.Pro163Leu) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
P163L (p.Pro163Leu) variant details
- p.Pro163Leu
- TOPMed rs1186118901
- gnomAD rs1186118901
- Missense
- Variant Prioritization Score for Impact Estimate 0.226
- REVEL 0.16
- MetaLR 0.11
- MetaSVM -0.99
- CADD 16.50
- PolyPhen-2 0.02
- SIFT 0.18
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available