M23V (p.Met23Val) variant of TRAF6 (TNF receptor-associated factor 6)
M23V (p.Met23Val) in TRAF6 (TNF receptor-associated factor 6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
M23V (p.Met23Val) variant details
- p.Met23Val
- rs747559755
- ExAC rs747559755
- gnomAD rs747559755
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.356
- REVEL 0.21
- MetaLR 0.33
- MetaSVM -0.53
- CADD 19.80
- PolyPhen-2 0.00
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available