M131L (p.Met131Leu) variant of TRAF6 (TNF receptor-associated factor 6)
M131L (p.Met131Leu) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
M131L (p.Met131Leu) variant details
- p.Met131Leu
- ExAC rs758390119
- gnomAD rs758390119
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.09
- MetaLR 0.03
- MetaSVM -1.03
- CADD 21.60
- PolyPhen-2 0.00
- SIFT 0.93
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available